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A review article by representatives of the Lomonosov Institute of Fine Chemical Technologies under the title “Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications” was included in the Editor's Choice Articles list. At the Lomonosov Institute of Fine Chemical Technologies at the Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry named after N.A. Preobrazhensky, students, together with researchers, work daily to create substances that are unique in their structure. Active components are to be used for the treatment of oncological diseases by various physical and chemical methods.

The article was published by A.I. Nichugovsky, assistant professor at the Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry named after N.A. Preobrazhensky and M.A. Maslov, professor of the same Department, and G.C. Tron, professor of the University of Eastern Piedmont (Novara, Italy) in the Molecules Q2 quartile, in the “Editor's Choice Articles” collection.

Editor's Choice articles are based on recommendations from scientific editors of MDPI journals from all around the world. Editors select a small number of articles recently published in the journal that they believe will be of particular interest to the authors or have proven important in a certain field.

“It is common knowledge that natural polyamines are found in almost all cells of living organisms, but in cancer cells their number increases significantly. This helps to use these cells as targets for cancer treatment. In our work, we have collected and analyzed the already known methods for the synthesis of polyamines and obtained our compounds, which are not inferior in efficiency to analogues abroad. In future, we plan to study the mechanism of cancer cell death, study molecular dynamics and share the results of our discoveries with the world,” said Artyom Nichugovsky, postgraduate student at ����Vlog��ý MIREA

The article is devoted to the synthesis of polyamines and their conjugates, which are promising agents for antitumor therapy. The synthesis of polyamines and their conjugates is a very difficult process due to the poliamines high polarity, low stability, and multi-stage synthesis. The article describes various methods used in the process, and studies the related problem with an emphasis on the use of the multicomponent Ugi reaction, which makes it possible to assemble polyamine scaffolds from simple compounds in two stages.

Over the past decade, hundreds of PA conjugates that have shown high antitumor and antimicrobial activity have been synthesized. Some of them are in the first and second stages of clinical trials.

The article is available at the link .